产品货号：
GS4540
中文名称：
重组人TWEAK Receptor
英文名称：
Recombinant Human TNF-related Weak Inducer of Apoptosis Receptor
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 5.6kDa,a single non-glycosylated polypeptide chain containing 53 amino acids.
储存条件：冷冻（-20℃）
概述
Human TNF-related weak inducer of apoptosis receptor(TWEAKR)also known as Tumor necrosis factor receptor superfamily member 12A precursor(gene name TNFRSF12A)or fibroblast growth factor-inducable 14 kDa protein,is distantly related to the TNFR family,containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain(DD)cytoplasmic region.It is expressed in the spleen,thymus,peripheral blood lymphocytes,colon,and small intestine.Signal transduction by TWEAK receptor can be activated by either the membrane anchored or the soluble TWEAK.In addition,It plays a role in TWEAK-induced endothelial cell migration,proliferation,and angiogenesis.Human and mouse TWEAK R share 82%a.a.sequence identity.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人TWEAK Receptor，TWEAK Receptor, Human
储存条件：冷冻（-20℃）
概述
Human TNF-related weak inducer of apoptosis receptor(TWEAKR)also known as Tumor necrosis factor receptor superfamily member 12A precursor(gene name TNFRSF12A)or fibroblast growth factor-inducable 14 kDa protein,is distantly related to the TNFR family,containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain(DD)cytoplasmic region.It is expressed in the spleen,thymus,peripheral blood lymphocytes,colon,and small intestine.Signal transduction by TWEAK receptor can be activated by either the membrane anchored or the soluble TWEAK.In addition,It plays a role in TWEAK-induced endothelial cell migration,proliferation,and angiogenesis.Human and mouse TWEAK R share 82%a.a.sequence identity.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by inhibiting TWEAK-dependent proliferation of human umbilical vein endothelial cells(HUVEC)is less than 30ng/ml,corresponding to a specific activity of>3.3×104 IU/mg,in the presence of 15 ng/ml of rHuTWEAK. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuTWEAK Receptor as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP |
相关搜索：重组人TWEAK Receptor，TWEAK Receptor, Human